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Answer:
 Figure 1: Loosely cohesive tumour cells with prominent nucleoli & cytoplasmic pigments (CS, Pap, 400x) |
 Figure 2: A cluster of tumour cells with brown cytoplasmic pigments & hyperchromatic nuclei (LBC, Pap, 400x) |
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Figure 3: S-100-positive tumour cells (vaginal
biopsy, S-100 protein, 400x) |
 Figure 4: HMB-45-positive tumour cells (vaginal biopsy, HMB-45, 400x) |
Discussion:
Primary malignant melanoma in female genital tract is race (~7% of all melanomas in women)
Often arises in vulva or vagina
In Pap smears, melanoma cells are
loosely dispersed. They are slightly smaller than parabasal cells,
relatively monotonous and contain hyperchromatic nuclei, prominent
nucleoli and dusty cytoplasmic pigments